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And just like that, we're living in the future. Over the last decade, scientists have been figuring out how to print all kinds of things, from printed art to prosthetics to food to braces, and it seems there's a printing solution for any need. And maybe there is because researchers at the Wake Forest Institute for Regenerative Medicine have just figured out how to make bioprinted skin, which will end up being a game changer for healing severe wounds like burns and deep lacerations.
Bioprinted skin made from human cells is a reality and will change healthcare forever.
According to Interesting Engineering, scientists have created bioprinted skin that's not just skin-deep but functions remarkably like the real deal. They've already tested the bioengineered skin on pigs with severe wounds and will soon be experimenting on people with the hope that this printed skin will heal wounds, burns, and various other skin injuries.
The bioprinted skin is a remarkable achievement as it replicates all three essential layers of real human skin: the hypodermis, epidermis, and dermis. While testing the bioengineered skin on pigs, researchers confirmed that the grafts generated improved wound closure and significant skin regeneration even on full-thickness wounds.
The scientists confirmed in the study, which was published in Science Translational Medicine, that the experiment showcased progress in bioprinted skin research, enhancing "the regeneration and production of native-like skin and suggests that bioprinted skin may be applicable for human clinical use." This breakthrough holds immense promise for the medical field and could address a pressing need.
The bioprinted skin is a remarkable achievement as it replicates all three essential layers of real human skin: the hypodermis, epidermis, and dermis.
The need for bioprinted skin arises from the considerable challenges associated with treating full-thickness wounds caused by severe injuries or burns. In the United States alone, nearly half a million people require treatment for such wounds annually, incurring a staggering cost of $2 billion.
Traditionally, doctors have relied on autologous skin grafting to treat these wounds, a procedure that involves transplanting healthy skin from one part of a patient's body to the damaged area. While this method has proven effective for many patients, it does have limitations, mainly in burn victims who may not have enough skin to harvest for the grafts. Bioprinted skin can fix this problem, as all doctors would need is a few cells in order to engineer a bioprinted skin graft for the patient.
And just like that, we're living in the future. Over the last decade, scientists have been figuring out how to print all kinds of things, from printed art to prosthetics to food to braces, and it seems there's a printing solution for any need. And maybe there is because researchers at the Wake Forest Institute for Regenerative Medicine have just figured out how to make bioprinted skin, which will end up being a game changer for healing severe wounds like burns and deep lacerations.
Bioprinted skin made from human cells is a reality and will change healthcare forever.
According to Interesting Engineering, scientists have created bioprinted skin that's not just skin-deep but functions remarkably like the real deal. They've already tested the bioengineered skin on pigs with severe wounds and will soon be experimenting on people with the hope that this printed skin will heal wounds, burns, and various other skin injuries.
The bioprinted skin is a remarkable achievement as it replicates all three essential layers of real human skin: the hypodermis, epidermis, and dermis. While testing the bioengineered skin on pigs, researchers confirmed that the grafts generated improved wound closure and significant skin regeneration even on full-thickness wounds.
The scientists confirmed in the study, which was published in Science Translational Medicine, that the experiment showcased progress in bioprinted skin research, enhancing "the regeneration and production of native-like skin and suggests that bioprinted skin may be applicable for human clinical use." This breakthrough holds immense promise for the medical field and could address a pressing need.
The bioprinted skin is a remarkable achievement as it replicates all three essential layers of real human skin: the hypodermis, epidermis, and dermis.
The need for bioprinted skin arises from the considerable challenges associated with treating full-thickness wounds caused by severe injuries or burns. In the United States alone, nearly half a million people require treatment for such wounds annually, incurring a staggering cost of $2 billion.
Traditionally, doctors have relied on autologous skin grafting to treat these wounds, a procedure that involves transplanting healthy skin from one part of a patient's body to the damaged area. While this method has proven effective for many patients, it does have limitations, mainly in burn victims who may not have enough skin to harvest for the grafts. Bioprinted skin can fix this problem, as all doctors would need is a few cells in order to engineer a bioprinted skin graft for the patient.
Instant evolution: AI designs new robot from scratch in seconds
But the AI program is not just fast. It also runs on a lightweight personal computer and designs wholly novel structures from scratch.
This stands in sharp contrast to other AI systems, which often require energy-hungry supercomputers and colossally large datasets. And even after crunching all that data, those systems are tethered to the constraints of human creativity — only mimicking humans’ past works without an ability to generate new ideas.
“We discovered a very fast AI-driven design algorithm that bypasses the traffic jams of evolution, without falling back on the bias of human designers,” said Northwestern’s Sam Kriegman, who led the work. “We told the AI that we wanted a robot that could walk across land. Then we simply pressed a button and presto! It generated a blueprint for a robot in the blink of an eye that looks nothing like any animal that has ever walked the earth. I call this process ‘instant evolution.’”
David Matthews, a scientist in Kriegman’s laboratory, is the paper’s first author. Kriegman and Matthews worked closely with co-authors Andrew Spielberg and Daniela Rus (Massachusetts Institute of Technology) and Josh Bongard (University of Vermont) for several years before their breakthrough discovery.
Exploring the potential of artificial life
In early 2020, Kriegman garnered widespread media attention for developing xenobots, the first living robots made entirely from biological cells. Now, Kriegman and his team view their new AI as the next advance in their quest to explore the potential of artificial life. The robot itself is unassuming — small, squishy and misshapen. And, for now, it is made of inorganic materials. But Kriegman says it represents the first step in a new era of AI-designed tools that, like animals, can act directly on the world.
“When people look at this robot, they might see a useless gadget,” Kriegman said. “I see the birth of a brand-new organism.”
Zero to walking in seconds
While the AI program can start with any prompt, Kriegman and his team began with a simple request to design a physical machine capable of walking on land. That’s where the researchers’ input ended and the AI took over.
The computer started with a block about the size of a bar of soap. It could jiggle but definitely not walk. Knowing that it had not yet achieved its goal, AI quickly iterated on the design. With each iteration, the AI assessed its design, identified flaws and whittled away at the simulated block to update its structure. Eventually, the simulated robot could bounce in place, then hop forward and then shuffle. Finally, after just nine tries, it generated a robot that could walk half its body length per second — about half the speed of an average human stride.
The entire design process — from a shapeless block with zero movement to a full-on walking robot — took just 26 seconds on a laptop.
“Now anyone can watch evolution in action as AI generates better and better robot bodies in real time,” Kriegman said. “Evolving robots previously required weeks of trial and error on a supercomputer, and of course before any animals could run, swim or fly around our world, there were billions upon billions of years of trial and error. This is because evolution has no foresight. It cannot see into the future to know if a specific mutation will be beneficial or catastrophic. We found a way to remove this blindfold, thereby compressing billions of years of evolution into an instant.”
Rediscovering legs
All on its own, AI surprisingly came up with the same solution for walking as nature: legs. But unlike nature’s decidedly symmetrical designs, AI took a different approach. The resulting robot has three legs, fins along its back, a flat face and is riddled with holes.
“It’s interesting because we didn’t tell the AI that a robot should have legs,” Kriegman said. “It rediscovered that legs are a good way to move around on land. Legged locomotion is, in fact, the most efficient form of terrestrial movement.”
To see if the simulated robot could work in real life, Kriegman and his team used the AI-designed robot as a blueprint. First, they 3D printed a mold of the negative space around the robot’s body. Then, they filled the mold with liquid silicone rubber and let it cure for a couple hours. When the team popped the solidified silicone out of the mold, it was squishy and flexible.
Now, it was time to see if the robot’s simulated behavior — walking — was retained in the physical world. The researchers filled the rubber robot body with air, making its three legs expand. When the air deflated from the robot’s body, the legs contracted. By continually pumping air into the robot, it repeatedly expanded then contracted — causing slow but steady locomotion.
A curious design
While the evolution of legs makes sense, the holes are a curious addition. AI punched holes throughout the robot’s body in seemingly random places. Kriegman hypothesizes that porosity removes weight and adds flexibility, enabling the robot to bend its legs for walking.
“We don’t really know what these holes do, but we know that they are important,” he said. “Because when we take them away, the robot either can’t walk anymore or can’t walk as well.”
Overall, Kriegman is surprised and fascinated by the robot’s design, noting that most human-designed robots either look like humans, dogs or hockey pucks.
“When humans design robots, we tend to design them to look like familiar objects,” Kriegman said. “But AI can create new possibilities and new paths forward that humans have never even considered. It could help us think and dream differently. And this might help us solve some of the most difficult problems we face.”
Although the AI’s first robot can do little more than shuffle forward, Kriegman imagines a world of possibilities for tools designed by the same program. Someday, similar robots might be able to navigate the rubble of a collapsed building, following thermal and vibrational signatures to search for trapped people and animals, or they might traverse sewer systems to diagnose problems, unclog pipes and repair damage. The AI also might be able to design nano-robots that enter the human body and steer through the blood stream to unclog arteries, diagnose illnesses or kill cancer cells.
“The only thing standing in our way of these new tools and therapies is that we have no idea how to design them,” Kriegman said. “Lucky for us, AI has ideas of its own.”